Adetokunbo Olawuyi, DDS, MMSc, MSc

Assistant Professor of Oral and Maxillofacial Pathology

Dr. Olawuyi’s research has focused on the impact of omega-3 fatty acid–enriched specialized pro-resolving lipid mediators (SPMs) on periodontal regeneration using a large animal model (Göttingen pigs). Periodontitis, an inflammatory disease caused by the interplay between microbial biofilm and host immune response, leads to destruction of the supporting structures of the teeth. Uncontrolled inflammation remains a major impediment to tissue engineering, limiting predictable regeneration of hard and soft tissues lost to periodontal disease.

SPMs are biosynthesized from essential polyunsaturated fatty acids and play a critical role in promoting resolution of inflammation. They also enhance stem cell proliferation and differentiation, supporting tissue repair and regeneration. Dr. Olawuyi’s work demonstrates that dietary supplementation with omega-3–enriched SPMs enhance bone regeneration, stimulate endogenous production of pro-resolving mediators and reduce pro-inflammatory mediators. This research has shown significant improvements in tissue healing and bone regeneration in the Göttingen pig model, advancing potential therapeutic strategies in periodontal care.