Ehab Sarsour, MSc, PhD

Ehab Sarsour, PhD
Assistant professor of Cellular and Molecular Biology 

Research Interest: Aging and age associated diseases including cancer 

Dr. Sarsour research interests focus on the molecular mechanisms that regulate proliferative properties of normal and cancer cells. Dr. Sarsour proposed that two separate, but interdependent pathways could regulate cellular longevity in normal cells: a redox-sensitive checkpoint regulating transition from quiescence to proliferation also known as chronological life span followed by telomeric attrition controlling the “mitotic clock” known as replicative life span.

My research has shown that the antioxidant enzyme manganese superoxide dismutase protects quiescent normal human fibroblast regenerative capacity (chronological life span) by regulating mitochondrial reactive oxygen species and protecting mitochondrial morphology from age associated abnormalities. Dr. Sarsour work has evolved into examining the molecular mechanisms associated with oxidative stress during cellular aging and its effects on cancer progression. The scope of his current and future work is to understand how cellular redox status and reactive oxygen species regulate cell biology in human tissue and their effect on the microenvironment of diseased tissue.